Therapeutic Benefits of Induced Hypothermia

Pharmacological Management of Therapeutic Hypothermia-Induced Shivering

The role of therapeutic moderate hypothermia (32 to 34oC) has evolved in the past decade and become an essential part of management following post-cardiac arrest resuscitation.1 Additionally, this practice has gained momentum as a potential neuroprotective measure in patients following acute brain injury. However, achieving and maintaining the target temperature is challenging. The human body m...

Therapeutic hypothermia

Pioneer works on therapeutic hypothermia (TH) half a century ago already showed promising results but clinical application was limited by a lack of understanding of the underlying pathophysiology, lack of reliable method for temperature control and lack of intensive care facilities to deal with possible complications. More recently, 2 studies in 2002 supported the application of moderate TH (32...

Therapeutic Hypothermia

Therapeutic hypothermia has been advocated for neuroprotection in cardiac arrest-induced encephalopathy, neonatal hypoxic-ischemic encephalopathy, traumatic brain injury, stroke, hepatic encephalopathy, and spinal cord injury, and as an adjunct to certain surgical procedures. In this review, we address physiological mechanism of hypothermia to mitigate neurological injury, the trials that have ...

Induction of Therapeutic Hypothermia

Therapeutic hypothermia may be useful in various circumstances including stroke. However, core body temperature is normally tightly regulated. Even mild hypothermia in conscious subjects thus provokes vigorous thermoregulatory defenses which are potentially harmful in fragile patients. Furthermore, thermoregulatory responses are effective, which reduces the rate at which hypothermia can be indu...

Mild Induced Therapeutic Hypothermia for Survivors of Cardiac Arrest